Ethanol inhibits alcohol dehydrogenase and should be used for poisonings with methanol and ethylene glycol. A therapeutic goal is 100-150 mg/dl. This is accomplished by a loading dose of 0.8 gm/kg followed by an infusion of 130 mg/kg/hr. The blood level should be closely followed. In patients on dialysis, the infusion should be 250-350 mg/kg/hr since ethanol will also be removed in the dialysate. The intravenous route is preferable to prevent gastritis and more easily control absorption, but the oral route may be used. Ethanol therapy should be continued until the methanol or ethylene glycol level is zero.